Abstract

The role of insulin and IGF-1 signaling in longevity.


Author: Katic M, Kahn, CR.
Source: Cellular and Molecular Life Sciences 62, (2005): 320 - 343.
Publication Date: 1/1/2005

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Abstract

There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.