Evidence, in plain English

ALP Lipid Lab Library

A growing library of the omega-3 research we're following — summarized and categorized so you can find what matters to you.

Type

Population

RCT Nov 10, 2022

Omega-3 DHA May Lower ACE2 Levels and Block SARS-CoV-2 Cell Entry in Lab Studies

DHA reduced ACE2 protein levels in animal and human cell studies and blocked SARS-CoV-2 pseudovirus entry into cells, though human blood ACE2 levels were unchanged with supplementation.

ACE2 Covid Gene Expression Heart Health Immune System

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RCT Jan 1, 2023

Omega-3 and Blood Markers Linked to Heart and COVID-19 Risk in People with Low Vitamin D

In adults with low vitamin D, 8 weeks of omega-3 supplementation lowered the ACE/ACE2 blood marker ratio but also raised LDL cholesterol.

ACE2 Cholesterol Covid Heart Health

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Review/News Jan 6, 2025

Could Omega-3s Help COPD Patients Facing COVID-19?

This review outlines biological reasons COPD patients face higher COVID-19 risk and suggests omega-3s may help regulate inflammation and immunity, though clinical trials are still lacking.

ACE2 COPD Covid Immune System

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Observational Jan 1, 2026

Higher Omega-3 Levels and Vitamin D Linked to Better COVID-19 Outcomes

COVID-19 patients with higher blood omega-3 levels had lower odds of death and hospitalization, while higher vitamin D was linked to shorter hospital stays.

All Cause Mortality Covid General Wellness Immune System Omega 3 Index (O3i)

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Observational May 25, 2022

Lower Omega-3 Blood Levels Linked to More Severe COVID-19

Patients hospitalized with severe COVID-19 had significantly lower Omega-3 Index levels than those with mild illness.

Covid Diabetes Immune System Omega 3 Index (O3i)

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Review/News Feb 28, 2023

Higher Blood Levels of Omega-3 DHA Linked to Lower COVID-19 Risk and Severity

People with higher blood DHA (omega-3) levels had lower rates of testing positive for and being hospitalized with COVID-19 in a large UK population study.

Covid Immune System Omega 3 Index (O3i)

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ALP Lipid Lab Library

Omega-3 DHA May Lower ACE2 Levels and Block SARS-CoV-2 Cell Entry in Lab Studies

Omega-3 and Blood Markers Linked to Heart and COVID-19 Risk in People with Low Vitamin D

Could Omega-3s Help COPD Patients Facing COVID-19?

Higher Omega-3 Levels and Vitamin D Linked to Better COVID-19 Outcomes

Lower Omega-3 Blood Levels Linked to More Severe COVID-19

Higher Blood Levels of Omega-3 DHA Linked to Lower COVID-19 Risk and Severity

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