Evidence, in plain English

ALP Lipid Lab Library

A growing library of the omega-3 research we're following — summarized and categorized so you can find what matters to you.

Type

Population

Observational Sep 2, 2026

Severe COVID-19 Linked to Widespread Depletion of Omega-3 Reserves Throughout the Body

Fatal COVID-19 was associated with widespread depletion of EPA and DPA across body tissues, while DHA was often relatively preserved, especially in the brain.

Brain Cognition Covid Heart Health Immune System Membranes Metabolism

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RCT Nov 10, 2022

Omega-3 DHA May Lower ACE2 Levels and Block SARS-CoV-2 Cell Entry in Lab Studies

DHA reduced ACE2 protein levels in animal and human cell studies and blocked SARS-CoV-2 pseudovirus entry into cells, though human blood ACE2 levels were unchanged with supplementation.

ACE2 Covid Gene Expression Heart Health Immune System

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RCT Jan 1, 2023

Omega-3 and Blood Markers Linked to Heart and COVID-19 Risk in People with Low Vitamin D

In adults with low vitamin D, 8 weeks of omega-3 supplementation lowered the ACE/ACE2 blood marker ratio but also raised LDL cholesterol.

ACE2 Cholesterol Covid Heart Health

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Review/News Jan 6, 2025

Could Omega-3s Help COPD Patients Facing COVID-19?

This review outlines biological reasons COPD patients face higher COVID-19 risk and suggests omega-3s may help regulate inflammation and immunity, though clinical trials are still lacking.

ACE2 COPD Covid Immune System

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Observational Jan 1, 2026

Higher Omega-3 Levels and Vitamin D Linked to Better COVID-19 Outcomes

COVID-19 patients with higher blood omega-3 levels had lower odds of death and hospitalization, while higher vitamin D was linked to shorter hospital stays.

All Cause Mortality Covid General Wellness Immune System Omega 3 Index (O3i)

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Observational May 25, 2022

Lower Omega-3 Blood Levels Linked to More Severe COVID-19

Patients hospitalized with severe COVID-19 had significantly lower Omega-3 Index levels than those with mild illness.

Covid Diabetes Immune System Omega 3 Index (O3i)

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ALP Lipid Lab Library

Severe COVID-19 Linked to Widespread Depletion of Omega-3 Reserves Throughout the Body

Omega-3 DHA May Lower ACE2 Levels and Block SARS-CoV-2 Cell Entry in Lab Studies

Omega-3 and Blood Markers Linked to Heart and COVID-19 Risk in People with Low Vitamin D

Could Omega-3s Help COPD Patients Facing COVID-19?

Higher Omega-3 Levels and Vitamin D Linked to Better COVID-19 Outcomes

Lower Omega-3 Blood Levels Linked to More Severe COVID-19

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