The ALP Life Sciences team compiles and utilizes extensive research related to the science of ideal Omega-3 balance, absorption and ultimately, the plethora of benefits that they produce.
Explore the research that drives our mission to provide the best Omega-3 Fish Oil Supplement possible below.
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Human Milk Omega-3 Fatty Acid Composition Is Associated with Infant Temperament Jennifer Hahn-Holbrook, Adi Fish and Laura M. Glynn Breastfeeding: Short and Long-Term Benefits to Baby and Mother |
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The Influence of Omega-3 Fatty Acids on Skeletal Muscle Protein Turnover in Health, Disuse, and Disease Chris McGlory, Philip C. Calder, and Everson A. Nunes Frontiers in Nutrition | Sport and Exercise Nutrition |
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Omega-3 Fatty Acids and Adipose Tissue: Inflammation and Browning Nishan Sudheera Kalupahana; Bimba Lakmini Goonapienuwala; and Naima Moustaid-Moussa; Annual Review of Nutrition |
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Role of omega‐6 and omega‐3 fatty acids in fetal programming Nirajan Shrestha Simone L. Sleep James S.M. Cuffe Olivia J. Holland Anthony V. Perkins Suk Yu Yau Andrew J. McAinch Deanne H. Hryciw Clinical and Experimental Pharmacology and Physiology |
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Omega-6/Omega-3 Essential Fatty Acid Ratio: The Scientific Evidence Artemis P. Simopulos, Leslie G. Cleland Karger |
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Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin Lauren K Pettit, Christopher Varsanyi, James Tadros, Evros Vassiliou Lipids Health Dis. |
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May omega-3 fatty acid dietary supplementation help reduce severecomplications in Covid-19 patients? Pierre Weill, Claire Plissonneau, Philippe Legrand, Vincent Rioux, Ronan Thibault Biochimie |
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High Omega-6/Omega-3 Fatty Acid Ratio Diets and Risk of Noncommunicable Diseases: Is the Tissue, the Main Issue? Hilton Chaves; Ram Singh; Shairy Khan; Agnieszka Wilczynska; Toru Takahashi. The Role of Functional Food Security in Global Health |
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Role of diets rich in omega-3 and omega-6 in the development of cancer SaraHuerta-YépezabAna B.Tirado-RodriguezaOliverHankinsona Boletín Médico del Hospital Infantil de México |
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Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology SaraswotiKhadgeaJohn GrahamSharpbGeoffrey M.ThieleacdTimothy R.McGuireeLynell W.KlassencdMichael J.DuryeecHolly C.BrittonaAlicia J.DafferneraJordanBeckfPaul N.BlackfConcetta C.DiRussofJamesTalmadgeac The Journal of Nutritional Biochemistry Volume 52, February 2018, Pages 92-102 |
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Effect of Mediterranean Diet on Healthy Brain Aging: Involvement of Telomerase Virginia Boccardi, Clara Tinarelli, Patrizia Mecocci Academic Press |
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Leukocyte telomere length and diet in the apparently healthy, middleaged Asklepios population Tim De Meyer1, Sofe Bekaert2, Marc L. De Buyzere3, Dirk D. De Bacquer4, Michel R. Langlois5, Nitin Shivappa6, James R. Hébert6, Thierry C. Gillebert 3, Ernst R. Rietzschel3 & Inge Huybrechts4,7 Scientific Reports |
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The red blood cell proportion of arachidonic acid relates to shorter leukocyte telomeres in Mediterranean elders: A secondary analysis of a randomized controlled trial Tania-MarisaFreitas-Simoesa, Maria A. Blascoc, Nora Soberónc, Miguel Forondac, Dolores Corellabd, Eva M.Asensiobd, MercèSerra-MiraIrene, Rotha Carlos, Calvoab CintaValls-PedretabRicardo, P.Casaroli-MaranoeMónica, Doménechab Sujatha Rajaramf, Joan Sabatéf, Emilio Rosab, Aleix Sala-Vilaab Clinical Nutrition, Accepted 10 February 2018, Available online 17 February 2018 |
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Effectiveness of Omega-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease: A Meta-Analysis of Randomized Controlled Trials Xi-Xi He, Xiao-Li Wu, Ren-Pin Chen, Chao Chen, Xiao-Gang Liu, Bin-Jiao Wu, Zhi-Ming Huang PLOS One Published: October 6, 2016 |
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Association between erythrocyte omega-3 polyunsaturated fatty acid levels and fatty liver index in older people Meagan Rosea, Martin Veyseyb, Mark Lucockc, Suzanne Niblettb, Katrina Kingb, Surinder Bainesd, Manohar L. Garga Journal of Nutrition & Intermediary Metabolism Volume 5, September 2016, Pages 78–85 |
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Omega-3 fatty acids as a treatment for non-alcoholic fatty liver disease in children: A systematic review and meta-analysis of randomized controlled trials Lian-hui Chena, Yong-fen Wanga, , , Qing-hong Xua, Shan-Shan Chenb Clinical Nutrition Available online 23 December 2016 |
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Omega-3 fatty acids: Mechanisms of benefit and therapeutic effects in pediatric and adult NAFLD Anna Alisi, Giovanni Musso, Eleonora Scorletti, Philip C. Calder & Christopher D. Byrne Critical Reviews in Laboratory Science Pages 106-120 | Received 22 May 2015, Accepted 16 Aug 2015, Published online: 14 Oct 2015 |
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The Response of an Expert Panel to Nutritional Armor for the Warfighter: Can Omega-3 Fatty Acids Enhance Stress Resilience, Wellness, and Military Performance? Ian D. Coulter Military Medicine Volume 179 Issue 11S, November 2014, pp. 192-198 |
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The effect of a fish diet on serum lipids in healthy human subjects. T O von Lossonczy, A Ruiter, H C Bronsgeest-Schoute, C M van Gent, and R J Hermus Am J Clin Nutr August 1978 vol. 31 no. 8 1340-1346 |
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The effects of omega-3 and omega-6 fatty acids on in vitro prostate cancer growth. PK Pandalai, et al Anticancer Research [1996, 16(2):815-820] |
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Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial V. Nobili, G Bedogni, et al Arch Dis Child2011;96:350-353 doi:10.1136/adc.2010.192401 |
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Perturbation of the metabolism of fatty acids by partially hydrogenated vegetable oil. Hill EG, Johnson HB, et al. Proceedings of the National Academy of Sciences (USA)79 (1982)953-957. |
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Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Lawrence T, Willoughby DA, et al Nature Reviews Immunology 2 (2002): 787-795. |
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Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation Y Yan, et al Immunity, Volume 38, Issue 6, 1154-1163, 27 June 2013 |
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Review article: omega-3 fatty acids – a promising novel therapy for non-alcoholic fatty liver disease Masterton, Plevris and Hayes Aliment Pharmacol Ther 31, 679–692 |
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N-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Significantly Reduces Liver Oxidative Stress in High Fat Induced Steatosis R Valenzuela, A Espinosa, et al PLOS One |
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Mitochondrial dysfunction during in vitro hepatocyte steatosis is reversed by omega-3 fatty acid–induced up-regulation of mitofusin 2 Y Zhang, L Jiang, et al Metabolism Volume 60, Issue 6, June 2011, Pages 767–775 |
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Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis H.M. Parker, N.A. Johnson, et al Journal of Hepatology Volume 56, Issue 4, April 2012, Pages 944–951 |
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The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease H Shapiro, M Tehilla, J Attal-Singer, R Luzzatti, P Singer Clinical Nutrition Volume 30, Issue 1 |
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Omega-3 fatty acids – A promising novel therapy for non-alcoholic fatty liver disease (NAFLD) GS Masterton, JN Plevris, PC Hayes Alimentary Pharmacology & Therapeutics |
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Docosahexaenoic Acid Attenuates Hepatic Inflammation, Oxidative Stress, and Fibrosis without Decreasing Hepatosteatosis in a Ldlr-/- Mouse Model of Western Diet-Induced Nonalcoholic Steatohepatitis CN Depner, K Philbrick, DB Jump Journal of Nutrition |
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Short-term Consumption of Oral Omega-3 and Dry Eye Syndrome H. Kangari, et al Ophthalmology, May 2013 |
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Obesity and Diabetes in the Developing World. Hossain P, Kamar B, et.al., New England Journal of Medicine 356 (2007):213-216 |
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Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases A Simopoulos J Am Coll Nutr December 2002 vol. 21 no. 6 495-505 |
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n-3 Fatty acids for the treatment of inflammatory bowel diseases Andrea Belluzzia Proceedings of the Nutrition Society Vol. 61 / Issue 03, pp 391-395 |
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Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Markers in COPD W Matsuyama, et al Chest. 2005; 128(6):3817-3827. doi:10.1378/chest.128.6.3817 |
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Dietary n-3 Polyunsaturated Fatty Acids and Smoking-Related Chronic Obstructive Pulmonary Disease E Shahar, et al N Engl J Med 1994; 331:228-233 |
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Omega-3 Fatty Acids and Cardiovascular Disease Kris-Etherton PM, Harris WS, et al Arteriosclerosis, Thrombosis, and Vascular Biology. 2003; 23: 151-152 |
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Blood Levels of Long-Chain n–3 Fatty Acids and the Risk of Sudden Death Albert et.al., New England Journal of Medicine; 346: 1113-1118. |
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Trends and Disparities in Heart Disease, Stroke, and Other Cardiovascular Diseases in the US: Findings of the National Conference On Cardiovascular Disease Prevention. Cooper R, Cutler J, et.al. Circulation 102 (2000): 3137-3141. |
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Risk of Cardiovascular Events Associated With Selective COX-2 Inhibitors. Mukherjee D, Nissen SE, et. al JAMA 286 (2001) 954 - 959 |
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NSAIDS and Heart Failure Bleumink, GS, Feenstra J, et al Drugs (2003) 525-534 |
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Types of Fish Consumed and Fish Preparation Methods in Relation to Pancreatic Cancer Incidence K He, et al American Journal of Epidemiology; (2013) 177 (2): 152-160. |
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PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer N Habermann, et al Genes and Nutrition; January 2013, Volume 8, Issue 1, pp 115-126 |
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Anticancer activity of fish oils against human lung cancer is associated with changes in formation of PGE2 and PGE3 and Alteration of Akt Phosphorylation P Yang; Molecular Carciongenesis; 31 JAN 2013 |
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Omega-3 fatty acids in cancer P Calder and R Deckelbaum Current Opinion in Clinical Nutrition and Cancer Care; March 2013 - Volume 16 - Issue 2 - p 156–161 |
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Interaction of ?-3 polyunsaturated fatty acids with radiation therapy in two different colorectal cancer cell lines F Cai, et al Clinial Nutrition |
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Dietary ?-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer N Merendino, et al BioMed Research International; Volume 2013 (2013), Article ID 310186 |
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EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: Role of ROS accumulation, caspase-8 activation, and autophagy induction M Fukui, et al J. Cell. Biochem. Volume 114, Issue 1, pages 192–203, January 2013 |
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Omega-3 Fatty Acids to Augment Cancer Therapy W Hardman J. Nutr. November 1, 2002 vol. 132 no. 11 3508S-3512S |
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Consumption of Fish Products across the Lifespan and Prostate Cancer Risk J Torfadottir, et al PLoS ONE 8(4): e59799. doi:10.1371/journal.pone.0059799 |
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Dietary Omega-3 Fatty Acids, Cyclooxygenase-2 Genetic Variation, and Aggressive Prostate Cancer Risk V. Fradet, et al Clin Cancer Res 15; 2559 |
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Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-a K.H. Weylandt, L.F. Krause, et al Carcinogenesis (2011) 32 (6): 897-903. |
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Fish oil decreases macrophage tumor necrosis factor gene transcription by altering the NF-kappa B activity. Lo CJ, Chu KC, et al Journal of Surgical Research 82 (1999):216-221. |
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Eicosapentaenoic Acid: An inflammatory Omega-3 fat with potential clinical applications. Babcock T, Helton WS, et al., Nutrition 16 (2000):1116 - 1118, |
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n-3 Fatty acids and the metabolic syndrome Y Carpentier Am J Clin Nutr June 2006 vol. 83 no. 6 S1499-1504S |
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Additive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic women J Krebs, et al International Journal of Obesity (2006) 30, 1535–1544. doi:10.1038/sj.ijo.0803309 |
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Randomized trial of weight-loss-diets for young adults varying in fish and fish oil content I Thorsdottir, et al International Journal of Obesity (2007) 31, 1560–1566; doi:10.1038/sj.ijo.0803643 |
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Plasma n-3 Polyunsaturated Fatty Acids are negatively associated with obesity. M Micallef, et al The British Journal of Nutrition [2009, 102(9):1370-1374] |
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Anti-obesity effects of long-chain omega-3 polyunsaturated fatty acids J Buckley, P Howe Obesity Reviews: Volume 10, Issue 6, pages 648–659, November 2009 |
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Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca2+-dependent K+ channels T Hoshi, et al PNAS March 4, 2013 201221997 |
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Expert Opinion: Omega-3 Fatty Acids and Bleeding—Cause for Concern? W Harris American Journal of Cardiology; Volume 99, Issue 6, Supplement 1 , Pages S44-S46 |
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Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial. A. Stoll, et al Arch Gen Psychiatry 56(5):407-12. |
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Omega-3 fatty acid supplementation does not reduce risk of atrial fibrillation after coronary artery bypass surgery: a randomized, double-blind, placebo-controlled clinical trial. P Saravana, et. al Circ Arrhythm Electrophysiol. 2010 Feb;3(1):46-53. doi: 10.1161/CIRCEP.109.899633. Epub 2009 Dec 30. |
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N-3 Fatty Acids for the Prevention of Atrial Fibrillation After Coronary Artery Bypass Surgery L Calo, et al J Am Coll Cardiol. 2005;45(10):1723-1728. doi:10.1016/j.jacc.2005.02.079 |
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Diet and disease — the Israeli paradox — possible dangers of a high omega-6 polyunsaturated fatty acid diet. Elitaz B, Yam D, et al Israeli Journal of Medical Sciences 32 (1996):1134 - 1143 |
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Fish oil and rheumatoid arthritis: past, present and future M James, et al Proceedings of the Nutrition Society / Volume 69 / Issue 03 / August 2010, pp 316-323 |
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Dietary n-3 fatty acids and therapy for rheumatoid arthritis M James, et al Seminars in Arthritis and Rheumatism; Volume 27, Issue 2, October 1997, Pages 85–97 |
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Omega-3 fatty acids and inflammation T Mori, et al Current Atherosclerosis Reports; 2004, Volume 6, Issue 6, pp 461-467 |
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Understanding omega-3 polyunsaturated fatty acids. PC Calder, et al Postgrad Med. 2009 Nov;121(6):148-57. doi: 10.3810/pgm.2009.11.2083. |
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Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis P Geusens, et al Arthritis and Rheumatism; Volume 37, Issue 6, pages 824–829, June 1994 |
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NIH Fish Oil Information National Institutes of Health Medline Plus: A service of the U.S. National Library of Medicine |
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Dietary fish oil and olive oil supplementation in patients with Rheumatoid Arthritis clinical and immunologic effects J Kremer, et al Arthritis & Rheumatism Volume 33, Issue 6, pages 810–820, June 1990 |
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A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain R Goldberg, J Katz PAIN Volume 129, Issue 1 , Pages 210-223, May 2007 |
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n-3 polyunsaturated fatty acids, inflammation and immunity Calder PC Nutrition Research Journal |
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Interactions of saturated, n-6 and n-3 polyunsaturated fatty acids to modulate arachidonic acid metabolism. Garg ML, Thomson AM, et al February 1990 The Journal of Lipid Research, 31, 271-277 |
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Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression Adams PB, Lawson S, et al Lipids, March 1996, Volume 31, Issue 1, pp S157-S161 |
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Statin treatments alters serum N-3 and n-6 fatty acids in hypercholesterolemic patients. Harn JI, Hibbeln JR, et al., Prostaglandins, Leukotrienes, and Essential Fatty Acids 71 (2004):263-269. |
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Increased arachidonoate lipids after administration to man; effects on prostaglandin biosynthesis Seyberth HW, Oelz, O et.al. Clinical Pharmacology and Therapeutics 18 (1975)521- 529. |
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Association of adipose tissue arachidonic acid content with BMI and overweight children in Cypress and Crete. Savva SC, Chadjegeorgiou C, et. al. British Journal of Nutrition 91(2004):643-649 |
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Arachidonic Acid Toxicity: Can Arachidonic Acid Be A Physiological Mediator of Cell Death? Pompeia c, Lima T, et.al. Cell Biochemistry & Function 21 (2003): 97 - 104 |
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Arachidonic Acid and Prostaglandins Signalling Promoting Adipose Tissue Development– A Human Health Concern? Amri EZ, Negiel R Journal of Lipid Research 44 (20003): 271 - 279. |
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Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. Kark JD, Kaufmann NH, et al., American Journal of Clinical Nutrition 77 (2003) 796-802. |
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Eicosanoids and Inflammation; Prostaglandins in Clinical Practice Zurier RB Prostaglandins in Clinical Practice; New York Raven Press, edited by Watkins WD, Peterson MB, et. al. |
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Association Between (alpha) a-Tocopherol, (gamma) y-Tocopherol, Selenium, and Subsequent Prostate Cancer J Kathy, et al JNCI J Natl Cancer Inst (2000) 92 (24): 2018-2023. |
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Anti-inflammatory properties of a-(alpha) and y-(gamma) tocopherol E Reiter, et al Molecular Aspect of Medicine; Volume 28, Issues 5–6, October–December 2007, Pages 668–691 |
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Does Vitamin E Prevent or Promote Cancer? C Yang, et al Cancer Prev Res May 1, 2012 5; 701 |
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gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Q Jiang, et al Am J Clin Nutr. 2001 Dec;74(6):714-22. |
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New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine. K Hensley, et al Free Radic Biol Med. 2004 Jan 1;36(1):1-15. |
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Understanding omega-3 polyunsaturated fatty acids. PC Calder, et al Postgrad Med. 2009 Nov;121(6):148-57. doi: 10.3810/pgm.2009.11.2083. |
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NIH Fish Oil Information National Institutes of Health Medline Plus: A service of the U.S. National Library of Medicine |
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Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. Kark JD, Kaufmann NH, et al., American Journal of Clinical Nutrition 77 (2003) 796-802. |
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Bioavailability of omega-3 essential fatty acids from perilla seed oil. Kurowska EM, Dresser GK, et al Prostaglandins, Leukotrienes, and Essential Fatty Acids [2003, 68(3):207-212] |
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Dietary Intake of Fish versus Formulations Leads to Higher Plasma Levels of n 3 Fatty Acids Visioli F, Rise P, et.al. Lipids, 38; 415-418. |
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Human absorption of fish oil fatty acids as triacylglycerols, free acids, or ethyl esters Lawson L, Hughes B Biochemical and Biophysical Research Communications; Volume 152, Issue 1, 15 April 1988, Pages 328–335 |
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Bioavailability of n-3 Fatty Acid Formulations Dyerberg J, Madsen P, et.al Prostaglandins, Leukotrienes and Essential Fatty Acids Volume 83, Issue 3, September 2010, Pages 137–141 |
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Bioavailability of omega-3 long chain polyunsaturated fatty acids from foods Mu, H Department of Systems Biology, Technical University of Denmark |
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Effect of an enteric coated fish oil preparation on relapses in Crohn’s disease Belluzzi A, Brignola C, et.al NEJM, #24, Vol 334 |
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Fish Oil Triglycerides vs. Ethyl Esters Gross M, Klein E, et.al Lange Eye Care & Associates |
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Dietary Omega-3 Fatty Acid Deficiency and High Fructose Intake in the Development of Metabolic Syndrome, Brain Metabolic Abnormalities, and Non-Alcoholic Fatty Liver Disease Artemis P. Simopoulos Nutrients 2013, 5, 2901-2923; doi:10.3390/nu5082901 |
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Characteristics of fatty acid distribution is associated with colorectal cancer prognosis J Zhang, et al Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA); Volume 88, Issue 5, May 2013, Pages 355–360 |
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Relationship of Plasma Polyunsaturated Fatty Acids to Circulating Inflammatory Markers L Ferrucci, et al The Journal of Clinical Endocrinology & Metabolism February 1, 2006 vol. 91 no. 2 439-446 |
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The importance of the ratio of omega-6/omega-3 essential fatty acids A.P Simopoulos Biomedicine & Pharmacotherapy; Volume 56, Issue 8, October 2002, Pages 365–379 |
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Cardiovascular benefits of omega-3 fatty acids. von Schacky c, Harris WS Cardiovasc Res (2007) 73 (2): 310-315. |
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Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression Adams PB, Lawson S, et al Lipids, March 1996, Volume 31, Issue 1, pp S157-S161 |
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n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study Lemaitre, et.al., American Journal of Clinical Nutrition; 77: 319-325. |
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Serum Fatty Acids and the Risk of Coronary Heart Disease Simon et.al., American Journal of Epidemiology;142: 469-476. |
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Blood Levels of Long-Chain n–3 Fatty Acids and the Risk of Sudden Death Albert et.al., New England Journal of Medicine; 346: 1113-1118. |
Abstract | Open Link |
Statin treatments alters serum N-3 and n-6 fatty acids in hypercholesterolemic patients. Harn JI, Hibbeln JR, et al., Prostaglandins, Leukotrienes, and Essential Fatty Acids 71 (2004):263-269. |
Abstract | Open Link |
Association of adipose tissue arachidonic acid content with BMI and overweight children in Cypress and Crete. Savva SC, Chadjegeorgiou C, et. al. British Journal of Nutrition 91(2004):643-649 |
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The Importance of Omega-6/Omega-3 Fatty Acid Ratio In Cardiovascular Disease and Other Chronic Diseases Sinopoulos AP Experimental Biology and Medicine 233 (2008), 674-688. |
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The role of insulin and IGF-1 signaling in longevity. Katic M, Kahn, CR. Cellular and Molecular Life Sciences 62, (2005): 320 - 343. |