Your Genes May Influence How Fish Oil Affects Your Fatty Acid Levels
This large genetic study used data from over 200,000 people in the UK Biobank to look at how specific genes influence blood levels of polyunsaturated and monounsaturated fats, like omega-3s and omega-6s. Instead of just looking at genes that directly raise or lower these fat levels, the researchers searched for genes that affect how much these fat levels *vary* from person to person — a sign that something else, like diet or supplements, might be interacting with that gene.
They found 46 distinct genetic locations linked to variability in 14 different fatty acid measurements. When they tested whether fish oil supplement use interacted with these genes, six significant interactions turned up, most notably near a well-known fatty acid metabolism gene called FADS1/2, as well as two additional genes (ZPR1 and SUGP1/TM6SF2) not identified in earlier studies of gene-supplement interactions.
These interactions affected specific measures including DHA, total omega-3 levels, linoleic acid (an omega-6), and the omega-6 to omega-3 ratio.
What this means for you
This research suggests that genetic makeup, particularly variations near genes involved in fat metabolism, may partly explain why fish oil supplementation affects people’s blood fatty acid levels differently. It doesn’t change any recommendations about fish oil use, but it adds to the scientific understanding of why individual responses to omega-3 supplements can vary.
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Start the ALP ProtocolThis summary is for educational purposes only and is not medical advice. Always talk to your healthcare provider before making changes to your supplement routine.