A growing library of the omega-3 research we're following — summarized and categorized so you can find what matters to you.
In rats, replacing part of dietary olive oil with fish oil reduced ethanol-related liver stress and appeared to restore normal liver cell cleanup (autophagy) activity.
In mice, blocking the enzyme that activates omega-3 fats increased markers of muscle protein breakdown, suggesting omega-3s may help preserve muscle mainly by limiting degradation rather than boosting synthesis.
Combining omega-3 DHA with delta-tocotrienol reduced lipid droplet buildup and increased lipid breakdown (lipophagy) in triple-negative breast cancer cells grown in the lab.
In mice and cultured kidney cells, EPA supplementation helped restore impaired cellular 'clean-up' (autophagy) processes disrupted by excess dietary fat.
In heat-stressed mice, omega-3 fatty acids improved cognitive function and protected brain cells, apparently by restoring a cellular cleanup process (autophagy) through changes to the PI3K-Akt-mTOR signaling pathway.
In high-fat diet-fed mice, krill oil reduced weight gain and improved markers of fatty liver, blood sugar, and kidney function.
DHA-containing phospholipids showed a stronger preference for raft-like membrane domains than arachidonic acid-containing phospholipids, altering membrane organization.
In neonatal piglets, a plant-based omega-3 IV nutrition formula was linked to less brain inflammation and stronger energy and growth signaling in the brain compared to a fish-oil-based formula.
Pooled data from 17 trials found omega-3 supplementation modestly reduced patient-reported joint pain, morning stiffness, tender joints, and NSAID use over 3-4 months.